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Evo312

CAT: 0804-HY-169006Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169006Size:1 Each
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Description
Evo312 is a dose-dependent inhibitor of protein kinase CβI (PKCβI) (IC50 is 117.34 nM) . Evo312 induces PANC-GR (acquired gemcitabine-resistant PC cells) cell cycle arrest and apoptosis by inhibiting PKCβ1 protein expression. Evo312 has antiproliferative effects in pancreatic cancer cells PANC-1 and PANC-GR cells with IC50 of 0.08 μM and 0.07 μM, and in human normal pancreatic ductal epithelial cells HPDE6-c7 with IC50 of 2.95 μM. Evo312 exhibits antitumor activity in a PANC-GR cell transplantation mouse model[1].
CAS Number
2820245-53-0
UNSPSC
12352005
Target
Apoptosis; PKC
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/evo312.html
Smiles
O=C1C2=C(N(C3N1CCC4=C3NC5=CC=C(OC(C)=O)C=C45)C)C=CC=C2
Molecular Formula
C21H19N3O3
Molecular Weight
361.39
References & Citations
[1]Eun Seo Bae, et al. Evo312: An Evodiamine Analog and Novel PKCβI Inhibitor with Potent Antitumor Activity in Gemcitabine-Resistant Pancreatic Cancer. J Med Chem. 2024 Aug 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCβ

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CatalogName
GTR19237484-01Evo312

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