Human FGF R3 (IIIb) / FGF R3B / CD333 Protein, Fc Tag (MALS verified)

• Background:

  Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. The FGFR3 gene is at the human chromosomal locus 4p16.3 also encodes two isoforms: FGF R3 (IIIb) FGF R3 (IIIc) . Upregulated expression of FGFR3 protein is also found in a significant number of tumors. Additionally, FGFR3 has been found to trigger resistance to tamoxifen via the activation of the PLCγ signaling cascade.

• Description:

  Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. The FGFR3 gene is at the human chromosomal locus 4p16.3 also encodes two isoforms: FGF R3 (IIIb) FGF R3 (IIIc) . Upregulated expression of FGFR3 protein is also found in a significant number of tumors. Additionally, FGFR3 has been found to trigger resistance to tamoxifen via the activation of the PLCγ signaling cascade.

• Specifications:

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 65.0 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• Accession Number:

  P22607-2

• Expression Region:

  Glu 23 - Gly 377

• Host:

  HEK293

• Target:

  FGF R3 (IIIb)

• Conjugation:

  Unconjugated

• Tag:

  C-Fc

• Source:

  Human

• Stability:

  -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

• Endotoxin:

  1.0 EU per μg

• Purity:

  95%

• Bioactivity:

  Immobilized Human FGF basic, premium grade (Cat. No. BFF-H4117) at 5 μg/mL (100 μL/well) can bind Human FGF R3 (IIIb), Fc Tag (Cat. No. FGB-H5259) with a linear range of 2-39 ng/mL (QC tested).

• Format:

  Powder

• Buffer:

  PBS, pH7.4

• Additives:

  Trehalose

• Molecular Weight:

  65.0 kDa

• Additionnal Information:

  Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

• Shipping Conditions:

  RT

• Storage Conditions:

  -20°C

• Package Size:

  1mg*1

• Host or Source:

  HEK293

• Species:

  Human

• Protein ID:

  P22607-2

• Preservative:

  Trehalose