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Zanoterone

CAT: 0804-HY-105122-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105122-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zanoterone is an orally active antagonist of the androgen receptor (AR) with a Ki of 2.2 μM. Zanoterone blocks the binding of androgens such as testosterone and dihydrotestosterone (DHT), inhibiting the androgen signaling pathway, thereby reducing androgen-dependent prostate hyperplasia and prostate cancer growth[1].
CAS Number
107000-34-0
Product Name Alternative
WIN 49596
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/zanoterone.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])CC4=NN(S(C)(=O)=O)C=C4C2)([H])[C@@]5([H])[C@](CC3)([C@@](O)(CC5)C#C)C
Molecular Formula
C23H32N2O3S
Molecular Weight
416.58
References & Citations
[1]Juniewicz PE, et al. Effect of combination treatment with zanoterone (WIN 49596), a steroidal androgen receptor antagonist, and finasteride (MK-906), a steroidal 5 alpha-reductase inhibitor, on the prostate and testes of beagle dogs. Endocrinology. 1993 Aug;133 (2) :904-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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MBS5810575Zanoterone

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