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GW549390X

CAT: 0804-HY-160687Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-160687Size:1 Each
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Description
GW549390X is a dual inhibitor of Fluc and VEGFR2 with IC50 of 0.26 μM and 1.2 μM, respectively. GW549390X can bind to the ATP pocket of FLuc through the aniline side chain and is an ATP-competitive inhibitor of Fluc. GW549390X acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, with potential implications for Fluc reporter assays[1].
CAS Number
135307-33-4
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gw549390x.html
Solubility
10 mM in DMSO
Smiles
C1(NC2=NC=C(C3=CC=CC=C3)O2)=CC=CC=C1
Molecular Formula
C15H12N2O
Molecular Weight
236.27
References & Citations
[1]Dranchak P, et al. Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. PLoS One. 2013;8 (3) :e57888.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N,5-Diphenyl-2-oxazolamine

a VEGFR2 kinase inhibitor; structure in first source

CAS Number135307-33-4
PubChem CID5329404
IUPAC NameN,5-diphenyl-1,3-oxazol-2-amine
Molecular FormulaC15H12N2O
Molecular Weight236.27
XLogP3.9
Topological Polar Surface Area38.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count18
Formal Charge0
Complexity247
SMILES
C1=CC=C(C=C1)C2=CN=C(O2)NC3=CC=CC=C3
InChI
InChI=1S/C15H12N2O/c1-3-7-12(8-4-1)14-11-16-15(18-14)17-13-9-5-2-6-10-13/h1-11H,(H,16,17)
InChIKey
HFICAVMUTYFODG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N,5-Diphenyl-2-oxazolamine
CAS: 135307-33-4
CID: 5329404
Formula: C15H12N2O
MW: 236.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight236.27
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass236.094963011
Monoisotopic Mass236.094963011
Topological Polar Surface Area38.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity247
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19235299-01GW549390X

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