HDAC6-IN-3

HDAC6-IN-3

• CAS Number: 3023019-99-7
• UNSPSC Description: HDAC6-IN-3 (Compound 14), an antiprostate cancer agent, is a potent, orally active HDAC6 inhibitor with IC50s ranging from 0.02-1.54 μM for HDAC1/2/3/6/8/10. HDAC6-IN-3 is also an effective MAO-A (IC50=0.79 μM) and LSD1 inhibitor[1]. HDAC6-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: HDAC; Histone Demethylase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hdac6-in-3.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(CCCCCCC(NC1=CC=CC(CN(CC#C)C)=C1)=O)NO
• Molecular Weight: 345.44
• References & Citations: [1]Ojha R, et al. Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent. J Med Chem. 2021;64(24):17824-17845.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported