Recombinant Human MASP1 protein (His tag)

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CAT:

763-PDEH100826-02

Size:

20 µg

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Recombinant Human MASP1 protein (His tag)

Background: Mannan-Binding Lectin Serine Protease 1 (MASP-1) belongs to the peptidase S1 family. MASP1 contains two CUB domains, one EGF-like domain, one peptidase S1 domain and two Sushi (CCP/SCR) domains. MASP1 is primarily expressed in liver. MASP1 involved in the lectin pathway of the complement, performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. MASP1 is synthesized as a zymogen and activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. MASP1 is not directly involved in complement activation but may act as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP2. MASP1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. MASP1 is inhibited by SERPING1 and A2M.
Abbreviation: MASP1
Synonyms: CRARF, CRARF1, Complement Factor MASP-3, MASP-1, MASP1, Mannan-Binding Lectin Serine Protease 1, Mannose-Binding Lectin-Associated Serine Protease 1, PRSS5, RaRF, Serine Protease 5
UniProt: P48740
Accession Number: P48740
Host: E. coli
Origin Species: Human
Tag: N-His
Sequence: His 20-Ala 447
Field of Research: immunology
Purity: > 95% as determined by reducing SDS-PAGE.
Bioactivity: Not validated for activity
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Molecular Weight: 48 kDa
Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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