Isovaleramide

• Description :

  Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1][2][3][4].

• CAS Number :

  [541-46-8]

• Product Name Alternative :

  3-Methylbutanamide

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  GABA Receptor

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Isovaleramide.html

• Purity :

  98.0

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  CC(C)CC(N)=O

• Molecular Formula :

  C5H11NO

• Molecular Weight :

  101.15

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Giraldo SE, et al. Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii]. Biomedica. 2010 Apr-Jun;30 (2) :245-50.|[2]Yang K, et al. Isovaleramide attenuates ethylene glycol poisoning‐induced acute kidney injury and reduces mortality by inhibiting alcohol dehydrogenase activity in rats[J]. Basic & Clinical Pharmacology & Toxicology, 2024.|[3]Park H J, et al. Studies on the components of valerian and isovaleramide[J]. YAKHAK HOEJI, 2010, 54 (1) : 1-7.|[4]Manavi M A. Exploring Valeriana species: Unraveling anticonvulsant potential through phytochemistry and pharmacology. Future Natural Products, 2024, 9 (2) : 100-110.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 2