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AB182

CAT: 0804-HY-118894Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118894Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AB-182 is an aziridine derivative and antitumor agent.AB-182 shows synergistic antitumor effects in conjunction with x-irradiation. Intermediate hydrolysis products of AB-182 may block the repair of x-irradiation-induced breaks in the DNA strands by phosphorylating their free 3'-OH end groups.
CAS Number
54805-58-2
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Assay Protocol
https://www.medchemexpress.com/ab182.html
Smiles
O=C(NOP(N1C(C)(C1)C)(N2C(C)(C2)C)=O)OCC
Molecular Formula
C11H22N3O4P
Molecular Weight
291.28
References & Citations
[1]Bardos TJ, Dunn JA, Perlman ME. Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents. Int J Radiat Oncol Biol Phys. 1979;5 (9) :1653-1656. |[2]Wodinsky I, Clement J, Swiniarski J, Skura A. Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia. Int J Radiat Oncol Biol Phys. 1979;5 (9) :1677-1680.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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