KPT-251
CAT:
804-HY-117996-01
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KPT-251
- CAS Number: 1388841-50-6
- UNSPSC Description: KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity[1][2].
- Target Antigen: Apoptosis; CRM1
- Type: Reference compound
- Related Pathways: Apoptosis;Membrane Transporter/Ion Channel
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/kpt-251.html
- Purity: 99.92
- Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: FC(C1=CC(C(F)(F)F)=CC(C2=NN(/C=C\C3=NN=CO3)C=N2)=C1)(F)F
- Molecular Weight: 375.23
- References & Citations: [1]Etchin J, et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 2013 Jan;27(1):66-74.|[2]Salas Fragomeni RA, et al. CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF-mutant melanoma. Mol Cancer Ther. 2013 Jul;12(7):1171-9.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported