LY53857

CAT: 0804-HY-116680Size: 1 EachDry Ice: NoHazardous: No

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Description

LY53857 is a potent antagonist of vasoconstriction and serotonin-mediated 5-HT2 receptors. LY53857 did not reduce mean arterial blood pressure in spontaneously hypertensive rats (SHR) at doses that blocked the depressor response to serotonin and blocked central serotonin receptors. In addition, LY53857 was able to enhance neurotransmitter release in rat vas deferens and guinea pig ileal nerves[1].

CAS Number

60634-51-7

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ly53857.html

Smiles

OC(/C=C\C(O)=O)=O.CC(N1C2=C3C([C@]4([H])[C@@](N(C[C@@H](C4)C(OC(C)C(O)C)=O)C)([H])CC3=C1)=CC=C2)C

Molecular Formula

C27H36N2O7

Molecular Weight

500.58

References & Citations

[1]Cohen M L, et al. LY53857, a selective and potent serotonergic (5-HT2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat[J]. Journal of Pharmacology and Experimental Therapeutics, 1983, 227 (2) : 327-332.|[2]Cohen M L, et al. Receptor specificity of the 5HT2 receptor antagonist, LY53857[J]. Drug development research, 1985, 5 (4) : 313-321.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

LY53857

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