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Clusterin Antibody

CAT: 0800-V4007-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V4007-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, -Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P10909
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 150-300 from the human CLU protein was used as the immunogen for the Clusterin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CLU/4724
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Clusterin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Clusterin antibody is available for research use only.
Storage Conditions
Aliquot the Clusterin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Clusterin antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using Clusterin antibody (clone CLU/4724) . These results demonstrate the foremost specificity of the CLU/4724 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

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