Products for Research Use Only
RegisterLogin

YSY01A

CAT: 0804-HY-162885Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-162885Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
YSY01A is a proteasome inhibitor that can suppress cancer cell survival by inducing apoptosis (Apoptosis) . Its IC50 values are 51.0 nM for HEK293T, 9.2 nM for A549, 5.2 nM for MCF-7, 8.9 nM for MGC-803, and 35.4 nM for PC-3M cells. Additionally, YSY01A eliminates constitutive STAT3 signaling by downregulating gp130 and JAK2 in human A549 lung cancer cells. YSY01A holds promise for research in the field of cancer therapy[1].
CAS Number
1194235-46-5
UNSPSC
12352211
Target
Interleukin Related; JAK; Proteasome; STAT
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ysy01a.html
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=C(C=CC=C2)C2=C1)C(N[C@H](B(O)O)CC(C)C)=O)=O)C3=CN=CC=N3
Molecular Formula
C29H38BN5O5
Molecular Weight
547.45
References & Citations
[1]Huang W, et al. Proteasome Inhibitor YSY01A Abrogates Constitutive STAT3 Signaling via Down-regulation of Gp130 and JAK2 in Human A549 Lung Cancer Cells. Front Pharmacol. 2017 Aug 24;8:476.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; JAK2; STAT3

Alternative Products

CatalogName
GTR19238579-01YSY01A

Popular Products