JH-XVI-178
CAT:
804-HY-139875-05
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
JH-XVI-178
- CAS Number: 2648453-53-4
- UNSPSC Description: JH-XVI-178 is a highly efficient and selective CDK8/19 inhibitor, with IC50 values of 1 and 2 nM for CDK8 and CDK19, respectively. JH-XVI-178 has a low clearance rate and moderate oral pharmacokinetic properties[1].
- Target Antigen: CDK
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/jh-xvi-178.html
- Solubility: DMSO : 62.5 mg/mL (ultrasonic)
- Smiles: ClC1=NNC2=NC=C(C3=CC(C=NN4C)=C4C=C3)C(N5CCC6(CCNC6=O)CC5)=C21
- Molecular Weight: 435.91
- References & Citations: [1]Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported