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4F-DDC

CAT: 0804-HY-163461Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163461Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4F-DDC is a novel PARP1 inhibitor with an IC50 value of 82 nM. 4F-DDC induces DNA damage and activates the cGAS–STING pathway. 4F-DDC inhibits the growth of HCC-1937-derived tumor xenografts[1].
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4f-ddc.html
Solubility
10 mM in DMSO
Smiles
S=C(N/N=C/C1=CC(OC)=C(OC)C(Br)=C1Br)NC2=CC=C(F)C=C2
Molecular Formula
C16H14Br2FN3O2S
Molecular Weight
491.17
References & Citations
[1]Yonglong Jin, et al. A Novel Inhibitor of Poly (ADP- R ibose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line via the DNA D amage- A ctivated cGAS-STING Pathway. Chem Res Toxicol. 2024, 37, 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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