4F-DDC

4F-DDC

• UNSPSC Description: 4F-DDC is a novel PARP1 inhibitor with an IC50 value of 82 nM. 4F-DDC induces DNA damage and activates the cGAS–STING pathway. 4F-DDC inhibits the growth of HCC-1937-derived tumor xenografts[1].
• Target Antigen: PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/4f-ddc.html
• Solubility: 10 mM in DMSO
• Smiles: S=C(N/N=C/C1=CC(OC)=C(OC)C(Br)=C1Br)NC2=CC=C(F)C=C2
• Molecular Weight: 491.17
• References & Citations: [1]Yonglong Jin, et al. A Novel Inhibitor of Poly(ADP- R ibose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line via the DNA D amage- A ctivated cGAS-STING Pathway. Chem Res Toxicol. 2024, 37, 4.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported