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JNJ19567470

CAT: 0804-HY-107095Size: 1 EachDry Ice: NoHazardous: No
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Description
JNJ19567470 (R317573) is a selective, non-peptidergic CRF type 1 receptor (CRF1) antagonist. JNJ19567470 blocks NaLac-induced panic-like behaviour and cardiovascular responses. JNJ19567470 decreases regional glucose utilization in the amygdala, and attenuates anxiety responses[1][2].
CAS Number
724471-26-5
Product Name Alternative
R317573; CRA5626; TAI041
UNSPSC
12352005
Target
CRFR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
BrC1=CC(C)=C(N2C=C(C)C3=C(N4CCC(CC4)CO)N=C(C)N=C32)C(C)=C1
Molecular Formula
C22H27BrN4O
Molecular Weight
443.38
References & Citations
[1]Shekhar A, et al. A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactate-induced acute panic-like responses. Int J Neuropsychopharmacol. 2011 Apr;14 (3) :355-65.|[2]Sotiriou I, et al. Pharmacotherapy in smoking cessation: Corticotropin Releasing Factor receptors as emerging intervention targets. Neuropeptides. 2017 Jun;63:49-57.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-Piperidinemethanol, 1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo(2,3-d)pyrimidin-4-yl)-
CAS Number724471-26-5
PubChem CID10478567
IUPAC Name[1-[7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethylpyrrolo[2,3-d]pyrimidin-4-yl]piperidin-4-yl]methanol
Molecular FormulaC22H27BrN4O
Molecular Weight443.4
XLogP5
Topological Polar Surface Area54.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity517
SMILES
CC1=CC(=CC(=C1N2C=C(C3=C2N=C(N=C3N4CCC(CC4)CO)C)C)C)Br
InChI
InChI=1S/C22H27BrN4O/c1-13-9-18(23)10-14(2)20(13)27-11-15(3)19-21(24-16(4)25-22(19)27)26-7-5-17(12-28)6-8-26/h9-11,17,28H,5-8,12H2,1-4H3
InChIKey
GGRHUOGLCCJDDN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Piperidinemethanol, 1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo(2,3-d)pyrimidin-4-yl)-
CAS: 724471-26-5
CID: 10478567
Formula: C22H27BrN4O
MW: 443.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight443.4
XLogP35
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass442.13682
Monoisotopic Mass442.13682
Topological Polar Surface Area54.2 Ų
Heavy Atom Count28
Formal Charge0
Complexity517
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A24293-5JNJ19567470 5mg
A24293-1JNJ19567470 1mg
A24293-50JNJ19567470 50mg
A24293-10JNJ19567470 10mg

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