TW-37

CAT: 0421-27775-3Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0421-27775-3Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

TW-37 is a Bcl-2 inhibitor that has been shown to inhibit the angiogenic potential of endothelial cells in vitro. S-phase arrest and apoptosis in pancreatic cancer cell lines have been observed to be induced by TW-37. It binds to the Bcl-2 homology domain 3 (BH3) groove of Bcl-2 preventing the heterodimerization of proapoptotic proteins (such as Bid, Bim, and Bad) with Bcl-2 and subsequently allowing them to induce apoptosis. Recent studies indicate TW-37 is able to inhibit the growth of a broad range of cancer cells (such as breast, prostate, lymphoma, and pancreatic cancer), since it induces S-phase cell cycle arrest with regulation of several important cell cycle related genes, including p27, p57, E2F-1, cdc25A, CDK4, cyclin A, cyclin D1 and cyclin E.

Description

TW-37 is a potent small-molecule inhibitor that attenuates Bcl-2 activation and inhibits multiple Bcl-2 family members including Bcl-xL and Mcl-1. TW-37 also inhibits in vivo and in vitro the activation of Jagged-1 and Notch-1.

CAS Number

877877-35-5

Solubility

Soluble in DMSO (100 mM), ethanol (5 mM), and water (<1 mg/mL) .

Molecular Formula

C33H35NO6S

Shipping Conditions

Room Temperature (continental US) or Gel Packs

Storage Conditions

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Calculated Molecular Weight

573.7 Da

Chemical Information

TW-37

TW-37 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 2,3,4-trihydroxy-5-[2-(propan-2-yl)benzyl]benzoic acid with the amino group of 4-[(2-tert-butylphenyl)sulfonyl]aniline. It is a potent inhibitor of Bcl-2 family of proteins (Ki = 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL). It has a role as a radiosensitizing agent, a B-cell lymphoma 2 inhibitor, an antineoplastic agent, an angiogenesis inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a benzenetriol and a sulfone.

CAS Number	877877-35-5
PubChem CID	11455910
IUPAC Name	N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
Molecular Formula	C33H35NO6S
Molecular Weight	573.7
XLogP	7.8
Topological Polar Surface Area	132
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Heavy Atom Count	41
Formal Charge	0
Complexity	963

SMILES

CC(C)C1=CC=CC=C1CC2=CC(=C(C(=C2O)O)O)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C

InChI

InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38)

InChIKey

PQAPVTKIEGUPRN-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 877877-35-5

CID: 11455910

Formula: C33H35NO6S

MW: 573.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	573.7
XLogP3	7.8
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	573.21850901
Monoisotopic Mass	573.21850901
Topological Polar Surface Area	132 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	963
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
468369-01	TW-37
256983-01	TW 37

TW-37

Chemical Information

Alternative Products

Popular Products