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Parthenolide

CAT: 0421-27768-1Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0421-27768-1Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Parthenolide is a sesquiterpene lactone, a class of naturally occurring plant terpenoids, and the active principle of feverfew (Chrysanthemum parthenium) . Parthenolide has demonstrated anti-inflammatory, antisecretory and spasmolytic activity. Parthenolide has been shown to inhibit the release of various chemical mediators such as Cox-2, TNF-α and IL-1 in LPS-stimulated macrophages and activation of MAP kinase and NFκβ. Recent findings indicate that parthenolide binds to and directly inhibits Iκβ kinase. The compound has also been shown to block the production of thromboxane B2 and leukotriene B4.
Description
Parthenolide specifically inhibits HDAC1 without affecting other class I/II HDACs.
CAS Number
20554-84-1
Format
White to off-white crystalline solid.
Solubility
Soluble in DMSO (100 mg/mL) or 100% ethanol (20 mg/mL) .
Molecular Formula
C15H20O3
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
248.3 Da

Alternative Products

CatalogName
E1KS2341Parthenolide ((-) -Parthenolide)
MBS8506347-01Parthenolide ( (-)-Parthenolide)
MBS385623-01Parthenolide ((-)-Parthenolide)
A10698-50Parthenolide ((-) -Parthenolide) 50mg
N1315-SParthenolide
S2341-01(-) -Parthenolide

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