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P005091

CAT: 0421-27767-1Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0421-27767-1Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
USP7, known as herpes-associated-ubiquitin-specificprotease (HAUSP), is a deubiquitylating enzyme that regulates the levels of the oncoprotein HDM2 and its substrate, the tumor suppressor p53. P005091 accelerated the degradation of HDM2, while analogs of the compound induced dose- and time-dependent increases in the protein levels of p53 and p21. P005091 induced apoptosis in numerous cancer cell lines, including both p53+/+ and p53-mutant cancer cell lines. P005091 also downregulated claspin and phosphorylation of the DNA checkpoint kinase Chk1.
Description
P005091 is a selective, potent inhibitor of USP7 deubiquitylating activity.
CAS Number
882257-11-6
Solubility
Soluble in DMSO
Molecular Formula
C12H7Cl2NO3S2
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.
Calculated Molecular Weight
348.2 Da

Alternative Products

CatalogName
A3023-SP005091
MBS579450P5091 (P005091)
A13277-5P005091 5mg
A13277-100P005091 100mg
A13277-50P005091 50mg
A13277-10P005091 10mg
A13277-25P005091 25mg
A13277-2P005091 2mg
A13277-10mM-DP005091 10mM * 1mL in DMSO
145684P005091 (USP7 Inhibitor, 1-[5-[ (2,3-Dichlorophenyl) thio]-4-n itro-2-thienyl]ethanone) discontinued

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