NVP-BEP800

• Background:

  NVP-BEP800 binds to the N-terminal ATP-binding pocket of Hsp90. Hsp90 is a ubiquitously expressed molecular chaperone with ATPase activity involved in the conformational maturation and stability of key signaling molecules involved in cell proliferation, survival, and transformation. In BT-474 cells and A375 cells, NVP-BEP800 causes the Hsp90-p23 dissociation and client protein degradation (ErbB2) as well as the reduction of client protein phosphorylation (phospho-Akt) . Degradation of these oncogenic client proteins results in tumor cell growth arrest and death.

• Description:

  NVP-BEP800 is a novel, fully synthetic, oral inhibitor of Hsp90β with IC50value of 58 nM.

• Purity:

  ≥ 99%

• Format:

  Solid

• Solubility:

  ≥ 16 mg/mL in EtOH with gentle warming; ≥ 24.7 mg/mL in DMSO with gentle warming and ultrasonic; insoluble in H2O. For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Long-term storage in solution is not recommended. Not stable in diluted solutions.

• Molecular Formula:

  C21H23Cl2N5O2S

• Shipping Conditions:

  Room Temperature (continental US) or Gel Packs

• Storage Conditions:

  Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

• Calculated Molecular Weight:

  480.4 Da

• CAS Number:

  847559-80-2