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NSC697923

CAT: 0421-27765-2Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0421-27765-2Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NSC697923 selectively inhibits PMA-induced NF-?B activation, and also inhibits I?Bα phosphorylation by both RANKL and LPS. NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-?B activity in ABC-DLBCL cells. In addition, NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, and also induces apoptosis of primary DLBCL cells. In neuroblastoma (NB) cell lines, NSC697923 shows cytotoxic effect, and inhibits both anchorage-dependent and -independent colony formation.
Description
NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. It is believed to act by disrupting formation of the Ubc13:Ub conjugate. Shown to inhibit proliferation and survival of certain B-cell lymphoma cells.
CAS Number
343351-67-7
Solubility
Soluble in DMSO (20 mg/mL) .
Molecular Formula
C11H9NO5S
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
267.3 Da

Alternative Products

CatalogName
A8813-10NSC697923

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