PYR-41

• Description:

  PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM) . It blocks degradation of p53 and inhibits NF-kappaB-dependent pathways. PYR-41 also increases SUMOylation of proteins.

• Applications:

  Useful for inhibition of E1 ubiquitin conjugating enzymes

• Purity:

  > 98% by TLC.

• Format:

  Brown powder

• Solubility:

  Soluble in DMSO (100 mM)

• Molecular Formula:

  C17H13N3O7

• Shipping Conditions:

  Room Temperature or Gel Packs

• Storage Conditions:

  Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.

• Calculated Molecular Weight:

  371.3 Da

• CAS Number:

  418805-02-4