LDN-57444

• Description:

  LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 μM) . Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphologyin vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.

• Applications:

  Useful for the inhibition of Ubiquitin C-terminal Hydrolase (UCH-L1) in drug discovery studies.

• Purity:

  ≥ 98% by TLC.

• Format:

  Yellow powder

• Solubility:

  Soluble in DMSO (20 mg/mL)

• Molecular Formula:

  C17H11Cl3N2O3

• Shipping Conditions:

  Gel Packs

• Storage Conditions:

  Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.

• Calculated Molecular Weight:

  397.6 Da

• CAS Number:

  668467-91-2