LDN-57444

CAT: 0421-27706-1Size: 10 mgDry Ice: NoHazardous: No
CAT#:0421-27706-1Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 μM) . Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphologyin vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.
CAS Number
668467-91-2
Applications
Useful for the inhibition of Ubiquitin C-terminal Hydrolase (UCH-L1) in drug discovery studies.
Purity
≥ 98% by TLC.
Format
Yellow powder
Solubility
Soluble in DMSO (20 mg/mL)
Molecular Formula
C17H11Cl3N2O3
Shipping Conditions
Gel Packs
Storage Conditions
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.
Calculated Molecular Weight
397.6 Da

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