LDN-57444

• Description :

  LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 μM) . Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphologyin vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.

• Applications :

  Useful for the inhibition of Ubiquitin C-terminal Hydrolase (UCH-L1) in drug discovery studies.

• Purity :

  ≥ 98% by TLC.

• Format :

  Yellow powder

• Solubility :

  Soluble in DMSO (20 mg/mL)

• Molecular Formula :

  C17H11Cl3N2O3

• Shipping Conditions :

  Gel Packs

• Storage Conditions :

  Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.

• Calculated Molecular Weight :

  397.6 Da

• CAS Number :

  668467-91-2