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UPF 1069

CAT: 0421-27665-1Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0421-27665-1Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UPF 1069, a derivative of isoquinolinone, is a potent and selective inhibitor of poly- (ADP-ribose) polymerase 2 (PARP-2) that is capable of reducing PAR formation both in recombinant enzyme preparations and in nuclear extracts from PARP-1-/- fibroblasts. Although its inhibition towards PARP-2 is most selective among other PARP-2 inhibitors, UPF 1069 also inhibits PARP-1 with a lesser potency . Having been used to investigate the role of PARP-1 and PARP-2 in post-ischaemic brain damage, UPF 1069 enhances oxygen-glucose deprivation (OGD) injury in hippocampal slices.
CAS Number
1048371-03-4
Purity
≥ 98% by HPLC
Solubility
Soluble in DMSO
Molecular Formula
C17H13NO3
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
279.3 Da

Alternative Products

CatalogName
A4163-5.1UPF 1069
HY-171468CC-1069
407176UPF-1069

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