Products for Research Use Only
RegisterLogin

SRT1720

CAT: 0421-27655-2Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0421-27655-2Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. SRT1720 has similar activity in the body to the known SIRT1 activator resveratrol, but is 1000x more potent. It affects mitochondrial respiration in a Sirt1- and PGC-1α-dependent manner. SRT1720 has been demonstrated to enhance insulin sensitivity and improve measures of mitochondrial capacity and oxidative metabolism. Treatment of multiple myeloma (MM) cells with SRT1720 inhibits growth and induced apoptosis in MM cells resistant to conventional and bortezomib therapies without significantly affecting the viability of normal cells. SRT1720 is able to enhance the cytotoxic activity of bortezomib or dexamethasone. Anti-MM activity of SRT1720 is related to: 1) activation of caspase-8, caspase-9, caspase-3, poly (ADP) ribose polymerase; 2) increase in reactive oxygen species; 3) induction of phosphorylated ataxia telangiectasia mutated/checkpoint kinase 2 signaling; 4) decrease in vascular endothelial growth factor-induced migration of MM cells and associated angiogenesis; and 5) inhibition of nuclear factor-κB.
CAS Number
1001645-58-4
Purity
≥ 98% by HPLC
Solubility
Soluble in DMSO
Molecular Formula
C25H23N7OS • HCl
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
506.0 Da

1001645-58-4

PubChem
cas1001645-58-4
modify2026-05-17
descriptionsmall molecule activator of SIRT1 as therapeutics for the treatment of type 2 diabetes; structure in first source
synonyms
1001645-58-4SRT1720RefChem:932153
N-(2-(3-(piperazin-1-ylmethyl)imidazo(2,1-b)(1,3)thiazol-6-yl)phenyl)quinoxaline-2-carboxamide
SRT 1720 HydrochlorideSRT1720 HClSRT1720 Hydrochloride2060259-60-9
N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydrochloride
SRT 1720 (Hydrochloride)+ 15 more
PubChem LinkClick here

Alternative Products

CatalogName
MBS3600020-01SRT1720
A4180-100SRT1720 HCl
FP71690-01SRT1720 hydrochloride
A10862-10SRT1720 10mg
A10862-200SRT1720 200mg

Popular Products