S- (+) -Rolipram

• Background :

  Rolipram is a racemic drug that increases brain cAMP availability by inhibiting phosphodiesterase. The S- (+) -Rolipram enantiomer is 2-10x less potent than the R- (-) -Rolipram compound. PDE4B is involved in dopamine-associated and stress-related behaviours, and is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.

• Description :

  S- (+) -Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.

• Molecular Formula :

  C16H21NO3

• Shipping Conditions :

  Room Temperature (continental US) or Gel Packs

• Storage Conditions :

  Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

• Calculated Molecular Weight :

  275.3 Da

• CAS Number :

  85416-73-5