Roflumilast

CAT: 0421-27645-3Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0421-27645-3Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The enzyme PDE-4 is found mainly in inflammatory cells, and Roflumilast acts as a selective, long-acting inhibitor of PDE-4. It has anti-inflammatory effects and is under development as an orally administered drug for the treatment of inflammatory conditions of the lungs such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD) . In vitro studies show that roflumilast inhibits the production of inflammatory mediators in a variety of human immune cells, suggesting a role for reducing COPD-related inflammation. Roflumilast is also found to decrease glucose levels in patients with newly diagnosed type-2 diabetes since diabetes is an important comorbidity associated with COPD.

Description

Roflumilast is an orally active, selective inhibitor of phophodiesterase-4 (PDE-4) with IC50 value of 0.11 nM . Roflumilast displays anti-inflammatory and immunomodulatory in vitro.

CAS Number

162401-32-3

Molecular Formula

C17H14Cl2F2N2O3

Shipping Conditions

Room Temperature (continental US) or Gel Packs

Storage Conditions

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Calculated Molecular Weight

403.21 Da

Alternative Products

Catalog	Name
A4319-25	Roflumilast

Roflumilast

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