JW 55

• Background:

  Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2) . Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

• Description:

  Cell-permeable, reversible tankyrase 1 (PARP5a) and tankyrase 2 (PARP5b) inhibitor. Also inhibits the β-catenin mediated canonical Wnt pathway

• Purity:

  ≥ 98% by HPLC

• Solubility:

  Soluble in DMSO

• Molecular Formula:

  C25H26N2O5

• Shipping Conditions:

  Room Temperature (continental US) or Gel Packs

• Storage Conditions:

  Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.

• Calculated Molecular Weight:

  434.5 Da

• CAS Number:

  664993-53-7