JW 55

CAT: 0421-27633-1Size: 10 mgDry Ice: NoHazardous: No
CAT#:0421-27633-1Size:10 mg
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Background
Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2) . Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.
Description
Cell-permeable, reversible tankyrase 1 (PARP5a) and tankyrase 2 (PARP5b) inhibitor. Also inhibits the β-catenin mediated canonical Wnt pathway
CAS Number
664993-53-7
Purity
≥ 98% by HPLC
Solubility
Soluble in DMSO
Molecular Formula
C25H26N2O5
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.
Calculated Molecular Weight
434.5 Da

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