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AZD2461

CAT: 0421-27606-2Size: 10 mgDry Ice: NoHazardous: No
CAT#:0421-27606-2Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance.
Description
AZD2461 is a novel PARP inhibitor with low affinity for than Olaparib. AZD2641 is currently in Phase I clinical studies to treat solid tumors.
CAS Number
1174043-16-3
Purity
≥ 98% by HPLC
Solubility
Soluble in DMSO
Molecular Formula
C22H22FN3O3
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
395.4 Da

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MBS575844AZD2461

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