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A-966492

CAT: 0421-27601-2Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0421-27601-2Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A-966492 is one of the most potent PARP inhibitors. A-966492 displays excellent potency against the PARP-1 enzyme with a Ki of 1 nM and an EC50 of 1 nM in a whole cell assay. A-966492 significantly enhances the efficacy of TMZ in a dose-dependent manner. In addition, A-966492 is orally bioavailable across multiple species, crosses the blood?brain barrier, and appears to distribute into tumor tissue. A-966492 represents a promising, structurally diverse benzimidazole analogue and is being further characterized preclinically.
Description
A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.
CAS Number
934162-61-5
Purity
≥ 98% by HPLC
Solubility
Soluble in DMSO 65 mg/mL, Water <1 mg/mL, Ethanol <1 mg/mL
Molecular Formula
C18H17FN4O
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
324.4 Da

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A4160-10A-966492
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A10019-1A-966492 1mg

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