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Dicer, FLAG-Tag Recombinant

CAT: 0421-101532-1Size: 20 µgDry Ice: YesHazardous: No
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CAT#:0421-101532-1Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Dicer (also known as endoribonuclease Dicer or helicase with RNase motif) is a ribonuclease that participates in pre-microRNA (pre-miRNA) and double stranded RNA (dsRNA) cleavage. The cleavage of pre-miRNA into mature miRNA and formation of small interfering RNA (siRNA) from dsRNA are essential for gene regulation and DNA repair. Decreased levels of Dicer can result in Age-related Macular Degeneration (AMD), the most common age-related blindness. Dicer impairment is also involved in cancer and RNA-based viral infection. The development of small molecule inhibitors or other strategies that affect Dicer activity can provide new therapeutical avenues for cancer treatment and AMD prevention.
Description
Recombinant human Dicer (Endoribonuclease Dicer), full length, encompassing amino acids 2-1922 (end) . This construct contains an N-terminal Flag-tag.  The recombinant protein was affinity purified.
CAS Number
9000-83-3
UniProt
Q9UPY3
Tag
N-terminal FLAG-tag
Purity
≥ 85%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
220 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, and 20% glycerol

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