Anti-CD20 Functional Antibody

CAT: 0421-71209Size: 100 µgDry Ice: YesHazardous: No

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CAT#:0421-71209Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

CD20 is present in the membrane of mature, normal, and abnormal B cells, but not in immature B cells. This expression pattern made it an attractive target for antibody-based lymphoma treatment as immature B cells will not be affected and can replenish the B cell population. Rituximab was the first anti-CD20 monoclonal antibody to reach the clinic, and since its commercialization it has led to a decrease in the number of deaths due to B cell malignancy.

Description

Anti-CD20 Functional Antibody is a chimeric monoclonal antibody that recognizes human CD20. The antibody features the constant region of the human IgG1 isotype and the mouse variable region of rituximab (amino acids 142-184) . This antibody is cytotoxic to WIL2-S cells in the presence of the rabbit complement system. The recombinant antibody was affinity purified.

CAS Number

9007-83-4

UniProt

P11836

Applications

Detection of CD20 and functional studies involving CD20 in biochemical and cellular assays.

Purity

≥ 90%

Format

Aqueous buffer solution

Shipping Conditions

-80°C

Storage Conditions

At least 6 months at -80°C.

Calculated Molecular Weight

Heavy Chain: 51 kDa; Light Chain: 25 kDa

Formulation

8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol

UniProtKB · P11836

B-lymphocyte antigen CD20

CD20_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P11836
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MS4A1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A6NMS4, B4DT24, P08984, Q13963

Protein keywords

Technical term

3D-structurePharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

B-cell activation

Cellular component

Cell membraneMembrane

PTM

Disulfide bondLipoproteinPalmitatePhosphoprotein

Domain

TransmembraneTransmembrane helix

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