SDMA

• Description :

  SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.

• Product Name Alternative :

  Symmetric dimethylarginine; NG, NG'-Dimethyl-L-arginine

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; NF-κB; NO Synthase

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/SDMA.html

• Concentration :

  10mM

• Purity :

  99.00

• Solubility :

  DMSO : 67.5 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  N[C@@H](CCC/N=C(NC)/NC)C(O)=O

• Molecular Formula :

  C8H18N4O2

• Molecular Weight :

  202.25

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Bode-Böger SM, et al. Symmetrical dimethylarginine: a new combined parameter for renal function and extent ofcoronary artery disease.|[2]Schepers E, et al. Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.Clin J Am Soc Nephrol. 2011 Oct;6 (10) :2374-83.|[3]Nabity MB, et al. Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the EarlyDetection of Chronic Kidney Disease in Dogs. J Vet Intern Med. 2015 Jul-Aug;29 (4) :1036-44.|[4]Veldink H, et al. Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice. Nephrol Dial Transplant. 2013 Jun;28 (6) :1434-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [30344-00-4]