SDMA

CAT: 0804-HY-101410-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101410-01Size:5 mg
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Description
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.
CAS Number
[30344-00-4]
Product Name Alternative
Symmetric dimethylarginine; NG, NG'-Dimethyl-L-arginine
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; NF-κB; NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/SDMA.html
Concentration
10mM
Purity
99.00
Solubility
DMSO : 67.5 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N[C@@H](CCC/N=C(NC)/NC)C(O)=O
Molecular Formula
C8H18N4O2
Molecular Weight
202.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Bode-Böger SM, et al. Symmetrical dimethylarginine: a new combined parameter for renal function and extent ofcoronary artery disease.|[2]Schepers E, et al. Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.Clin J Am Soc Nephrol. 2011 Oct;6 (10) :2374-83.|[3]Nabity MB, et al. Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the EarlyDetection of Chronic Kidney Disease in Dogs. J Vet Intern Med. 2015 Jul-Aug;29 (4) :1036-44.|[4]Veldink H, et al. Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice. Nephrol Dial Transplant. 2013 Jun;28 (6) :1434-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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