IDO1/2-IN-1 (hydrochloride)
CAT:
804-HY-145280A-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IDO1/2-IN-1 (hydrochloride)
- CAS Number: 2310286-60-1
- UNSPSC Description: IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active[1].
- Target Antigen: Indoleamine 2,3-Dioxygenase (IDO)
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/ido1-2-in-1-hydrochloride.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: FC1=CC=C(C=C1Br)/N=C(C2=NON=C2NCCN3N=NC(COCCO)=C3)/NO.[H]Cl
- Molecular Weight: 521.73
- References & Citations: [1]He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported