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Odevixibat-d5

CAT: 0804-HY-109120SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109120SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Odevixibat-d5 is deuterated labeled Odevixibat. Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis[1].
Product Name Alternative
A4250-d5
UNSPSC
12352005
Target
Apical Sodium-Dependent Bile Acid Transporter; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
[2H]C1=C(C([2H])=C(C([2H])=C1[2H])N2CC(CCCC)(NS(=O)(C3=CC(OCC(N[C@H](C4=CC=C(C=C4)O)C(N[C@H](C(O)=O)CC)=O)=O)=C(C=C32)SC)=O)CCCC)[2H]
Molecular Formula
C37H43D5N4O8S2
Molecular Weight
745.96
References & Citations
[1]Baghdasaryan A, et al. Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.J Hepatol. 2016 Mar;64 (3) :674-81.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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