Mecamylamine (hydrochloride)-13C4,15N
CAT:
804-HY-B1395S1-02
Size:
5 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Mecamylamine (hydrochloride)-13C4,15N
- UNSPSC Description: Mecamylamine (hydrochloride)-13C4,15N is the 13C-labeled and 15N-labeled Mecamylamine hydrochloride. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier[1][2].
- Target Antigen: Isotope-Labeled Compounds; nAChR
- Type: Isotope-Labeled Compounds
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling;Others
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/mecamylamine-hydrochloride-13c4-15n.html
- Solubility: 10 mM in DMSO
- Smiles: [13C]C1([13C])C([15NH][13C])([13C])C2CCC1C2.[H]Cl
- Molecular Weight: 196.62
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Bacher I, et al. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009 Nov;10(16):2709-21.|[3]Ostroumov K, et al. Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur Biophys J. 2008 Apr;37(4):393-402.|[4]Rabenstein RL, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec;189(3):395-401.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported