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SHLP2

CAT: 0804-HY-P10409-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10409-02Size:10 mg
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Description
SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 binds to mitochondrial complex 1. SHLP2 improves mitochondrial metabolism by increasing respiration and biogenesis, reducing ROS, and decreasing mtDNA oxidation. SHLP2 also regulated energy homeostasis through the activation of hypothalamic neurons. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases, such as age-related macular degeneration and Parkinson’s disease[1][2].
CAS Number
1191923-93-9
Product Name Alternative
Small humanin-like peptide 2
UNSPSC
12352209
Target
Apoptosis; Reactive Oxygen Species (ROS)
Type
Peptides
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/shlp2.html
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N5[C@@H](CCC5)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N6[C@@H](CCC6)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N
Molecular Formula
C142H214N36O35S
Molecular Weight
3017.50
References & Citations
[1]Nashine S, et al. Effects of mitochondrial-derived peptides (MDPs) on mitochondrial and cellular health in AMD[J]. Cells, 2020, 9 (5) : 1102.|[2]Kim, S. J., et al., (2024) . A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Molecular psychiatry, 29 (2), 505–517. |[3]Kim, S. K., et al., (2023) . Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons. Nature communications, 14 (1), 4321.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH
CAS Number1191923-93-9
PubChem CID171716852
IUPAC Name(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoic acid
Molecular FormulaC142H214N36O35S
Molecular Weight3017.5
XLogP-4.4
Topological Polar Surface Area1170
Hydrogen Bond Donor Count41
Hydrogen Bond Acceptor Count40
Rotatable Bond Count94
Heavy Atom Count214
Formal Charge0
Complexity6840
SMILES
C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CC=CC=C8)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCSC)N)O
InChI
InChI=1S/C142H214N36O35S/c1-73(2)60-94(122(194)163-99(66-86-68-153-89-45-29-28-44-87(86)89)128(200)175-115(81(14)184)137(209)166-100(67-108(146)186)126(198)170-104(72-181)140(212)213)164-131(203)106-50-35-58-178(106)139(211)112(77(9)10)173-116(188)78(11)155-118(190)91(47-32-55-151-141(147)148)156-121(193)93(51-52-107(145)185)159-134(206)111(76(7)8)172-129(201)103(71-180)169-132(204)105-49-34-57-177(105)138(210)101(65-85-42-26-19-27-43-85)167-125(197)97(63-83-38-22-17-23-39-83)161-120(192)92(48-33-56-152-142(149)150)158-135(207)113(79(12)182)176-130(202)102(70-179)168-123(195)95(61-74(3)4)165-136(208)114(80(13)183)174-127(199)98(64-84-40-24-18-25-41-84)162-124(196)96(62-82-36-20-16-21-37-82)160-119(191)90(46-30-31-54-143)157-133(205)110(75(5)6)171-109(187)69-154-117(189)88(144)53-59-214-15/h16-29,36-45,68,73-81,88,90-106,110-115,153,179-184H,30-35,46-67,69-72,143-144H2,1-15H3,(H2,145,185)(H2,146,186)(H,154,189)(H,155,190)(H,156,193)(H,157,205)(H,158,207)(H,159,206)(H,160,191)(H,161,192)(H,162,196)(H,163,194)(H,164,203)(H,165,208)(H,166,209)(H,167,197)(H,168,195)(H,169,204)(H,170,198)(H,171,187)(H,172,201)(H,173,188)(H,174,199)(H,175,200)(H,176,202)(H,212,213)(H4,147,148,151)(H4,149,150,152)/t78-,79+,80+,81+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,110-,111-,112-,113-,114-,115-/m0/s1
InChIKey
YUVVZIHRQWDEPJ-OCEARBFSSA-N
Chemical Structure
2D Structure
2D structure of H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH
CAS: 1191923-93-9
CID: 171716852
Formula: C142H214N36O35S
MW: 3017.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight3017.5
XLogP3-4.4
Hydrogen Bond Donor Count41
Hydrogen Bond Acceptor Count40
Rotatable Bond Count94
Exact Mass3016.5826587
Monoisotopic Mass3015.5793038
Topological Polar Surface Area1170 Ų
Heavy Atom Count214
Formal Charge0
Complexity6840
Isotope Atom Count0
Defined Atom Stereocenter Count28
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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