H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA

H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA

• CAS Number: 202739-41-1
• UNSPSC Description: H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins[1][2].
• Target Antigen: Fluorescent Dye
• Type: Peptides
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/h-trp-phe-tyr-ser-po3h2-pro-arg-pna.html
• Solubility: 10 mM in DMSO
• Smiles: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](COP(O)(O)=O)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O)=O)NC([C@H](CC4=CC=CC=C4)NC([C@@H](N)CC5=CNC6=CC=CC=C56)=O)=O
• Molecular Weight: 1055.04
• References & Citations: [1]M B Yaffe, et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12;278(5345):1957-60.|[2]Kelly E Duncan, et al. Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. J Med Chem. 2011 Jun 9;54(11):3854-65.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported