Transcription factor Spi-C / SPIC
CAT:
800-V9223-20UG
Size:
20 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No




Transcription factor Spi-C / SPIC
- Description: The Ets transcription factor family is comprised of DNA-binding proteins that influence lymphoid development and activity and bind the consensus DNA site GGA(A/T) through a unique winged helix-turn-helix motif known as the Ets domain. Spi-B and Spi-C (also known as SPIC) are closely related Ets family members which share a conserved divergent sequence within the Ets domain that enables their binding to non-canonical AGAA sites. Spi-C is a 248 amino acid protein that localizes to the nucleus and, like other Ets family members, binds DNA as a monomer and plays a role in transcriptional regulation. Addi- tionally, Spi-C is thought to control the development of red pulp macrophages, thereby contributing to iron homeostasis and red blood cell recycling. Human Spi-C shares 65% amino acid identity with its mouse counterpart, suggesting a conserved role between species.
- UniProt: Q8N5J4
- Host: Mouse
- Immunogen: Recombinant full-length human Transcription factor Spi-C protein was used as the immunogen for the SPIC antibody.
- Clonality: Monoclonal
- Isotype: IgG2b
- Applications: FACS, IF
- Format: Purified
- Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
- Reconstitution: Aliquot the SPIC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
- Limitations: This SPIC antibody is available for research use only.