NMI Antibody / N-myc and STAT interactor / N-Myc Interactor

NMI Antibody / N-myc and STAT interactor / N-Myc Interactor

• Description: Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.
• CAS Number: 9007-83-4
• UniProt: Q13287
• Host: Mouse
• Immunogen: Recombinant full-length human N-Myc Interactor protein was used as the immunogen for the N-Myc Interactor antibody.
• Clonality: Monoclonal
• Isotype: IgG2b
• Applications: FACS
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Aliquot the N-Myc Interactor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This N-Myc Interactor antibody is available for research use only.