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GTF2IRD2 Antibody / GTF2IRD2 alpha

CAT: 0800-V9214-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9214-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The TFII-I family contains two highly homologous 949 amino acid proteins, GTF2IRD2 (also called GTF2IRD2 alpha and GTF2IRD2A) and GTF2IRD2B. Localizing to the nucleus, these proteins are ubiquitously expressed and contain two GTF2I- like repeats. Encoded by a gene mapping to human chromosome 7q11.23, GTF2IRD2 and GTF2IRD2B are located in the Williams-Beuren syndrome (WBS) critical region. The deletion of genes located within this region results in WBS, possibly due to the unequal crossing over of highly homologous low-copy repeat sequences that flank the deleted region. WBS is an autosomal dominant genetic condition that is characterized by physical, cognitive and behavioral traits including facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies and neurologic and musculoskeletal abnormalities.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Western blot: 1-2 µg/mL
UniProt
Q86UP8
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human General transcription factor II-I repeat domain-containing protein 2A protein was used as the immunogen for the GTF2IRD2 antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
PCRP-GTF2IRD2-1B4
Applications
FACS, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the GTF2IRD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GTF2IRD2 antibody is available for research use only.
Storage Conditions
Aliquot the GTF2IRD2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the GTF2IRD2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using GTF2IRD2 antibody (clone PCRP-GTF2IRD2-1B4) . These results demonstrate the foremost specificity of the PCRP-GTF2IRD2-1B4 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

UniProtKB · Q86UP8

General transcription factor II-I repeat domain-containing protein 2A

GTD2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86UP8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GTF2IRD2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GTF2I repeat domain-containing protein 2A
EC number
—
Processing
—
Secondary accessions
A0A0A0MSY2, A8K5W6, B3KUZ2, Q69G40, Q6EKI8, Q6EKI9, Q6NVW2, Q6P7N8, Q86WX4, Q8ND85, Q8NDE5
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

DNA-binding

Cellular component

Nucleus

Technical term

Reference proteome

Domain

Repeat

Biological process

TranscriptionTranscription regulation

Disease

Williams-Beuren syndrome

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