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ICAM1 Antibody / CD54

CAT: 0800-V9194-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9194-100UGSize:100 µg
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Description
Recognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1) . It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1) . This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. ICAM-1 may also be related to progression and metastasis of tumors.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P05362
Host
Mouse
Reactivity
Human
Immunogen
A recombinant protein fragment was used as the immunogen for the ICAM1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
ICAM1/6917
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the ICAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ICAM1 antibody is available for research use only.
Storage Conditions
Aliquot the ICAM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the ICAM1 antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
IHC staining of FFPE human tonsil tissue with ICAM-1 antibody (clone ICAM1/6917) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P05362

Intercellular adhesion molecule 1

ICAM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05362
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ICAM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ICAM-1
EC number
—
Processing
Precursor
Secondary accessions
B2R6M3, Q5NKV7, Q96B50
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Molecular function

Host cell receptor for virus entryReceptor

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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