CCND1 Antibody

• Description :

  Cyclin D1 (CCND1), one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of Cyclin D1. This antibody is useful in identifying mantle cell lymphomas (CCND1+) from CLL/SLL and follicular lymphomas (CCND1-) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express CCND1.

• Specifications :

  The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

• UniProt :

  P24385

• Host :

  Mouse

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant full length human protein was used as the immunogen for this CCND1 antibody.

• Clonality :

  Monoclonal

• Isotype :

  IgG2a κ

• Clone :

  SPM587

• Applications :

  IHC-P

• Purity :

  Protein G affinity chromatography

• Format :

  Purified

• Buffer :

  Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

• Reconstitution :

  Store the CCND1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations :

  This CCND1 antibody is available for research use only.

• Storage Conditions :

  Store the CCND1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

• Formulation :

  Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*

• CAS Number :

  9007-83-4

• Location :

  Nuclear

• Image Legend :

  IHC: Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained with CCND1 antibody.