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FOXP3 Antibody

CAT: 0800-V9063IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V9063IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q9BZS1
Host
Mouse
Reactivity
Human
Immunogen
Full-length His-tagged mouse FOXP3 protein was used as the immunogen for this FOXP3 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM579
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the FOXP3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FOXP3 antibody is available for research use only.
Storage Conditions
Store the FOXP3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Predominantly nuclear, some cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human testicular carcinoma stained with FOXP3 antibody (SPM579) .

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