Recombinant Langerin Antibody / CD207

• Description:

  Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG) . BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

• Specifications:

  ELISA: 2-4 µg/mL (order BSA-free format for coating)

• UniProt:

  Q9UJ71

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 74-213 was used as the immunogen for the recombinant Langerin antibody.

• Clonality:

  Recombinant Monoclonal

• Isotype:

  IgG1 k

• Clone:

  RLGRN/1821

• Type:

  Recombinant

• Applications:

  ELISA

• Purity:

  Protein A/G affinity

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Aliquot the recombinant Langerin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This recombinant Langerin antibody is available for research use only.

• Storage Conditions:

  Aliquot the recombinant Langerin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  1 mg/mL in 1X PBS; BSA free, sodium azide free

• Applications Notes:

  Optimal dilution of the recombinant Langerin antibody should be determined by the researcher.

• CAS Number:

  9000-83-3

• Location:

  Cell surface and cytoplasmic

• Image Legend:

  SDS-PAGE analysis of purified, BSA-free recombinant Langerin antibody (clone rLGRN/1821) as confirmation of integrity and purity.