MBP Antibody

CAT: 0800-V8675-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V8675-20UGSize:20 µg
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Description
Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. MBP/4271 recognizes an epitope in the 129-138 region of MBP, useful in clinical diagnosis to detect MBP levels.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P02686
Host
Mouse
Reactivity
Human
Immunogen
The epitope for this MBP antibody has been mapped to amino acids 129-138 from the human protein.
Clonality
Monoclonal
Isotype
IgG2a
Clone
MBP/4271
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the MBP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MBP antibody is available for research use only.
Storage Conditions
Store the MBP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the MBP antibody should be determined by the researcher.
Location
Cell surface, cytoplasm
Image Legend
IHC staining of FFPE human brain with MBP antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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