ZAP70 Recombinant Antibody

• Description:

  ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.

• UniProt:

  P43403

• Host:

  Rabbit

• Immunogen:

  A portion of amino acids 247-382 from the human protein was used as the immunogen for the recombinant ZAP70 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG

• Type:

  Recombinant

• Applications:

  ELISA, IHC-P

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Reconstitution:

  Store the recombinant ZAP70 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This recombinant ZAP70 antibody is available for research use only.

• CAS Number:

  9000-83-3