FABP1 Antibody

CAT: 0800-V8550-100UGSize: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-V8550-100UGSize:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epithelium (E-FABP, psoriasis-associated FABP, PA-FABP), striated muscle and heart (H-FABP, mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP or FABP1), myelin (M-FABP) and testis (T-FABP) . FABP1 (L-FABP) expression is modulated by developmental, hormonal, dietary and pharmacological factors, and is required for cholesterol synthesis and metabolism.

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT

UniProt

P07148

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1-127 from the human protein was used as the immunogen for the FABP1 antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

FABP1/3486

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Store the FABP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This FABP1 antibody is available for research use only.

Storage Conditions

Store the FABP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the FABP1 antibody should be determined by the researcher.

Location

Cytoplasm, Nuclear

Image Legend

IHC staining of FFPE human kidney with FABP1 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P07148

Fatty acid-binding protein, liver

FABPL_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P07148
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: FABP1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: —

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

Cytoplasm

Ligand

Lipid-binding

Biological process

Transport

Product Datasheet

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Alternative Products

Catalog	Name
70R-3518	FABP1 antibody