Factor VII Antibody

Factor VII Antibody

• Description: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.
• CAS Number: 9007-83-4
• UniProt: P08709
• Host: Mouse
• Immunogen: A portion of amino acids 366-466 from the human protein was used as the immunogen for the F7 antibody.
• Clonality: Monoclonal
• Isotype: IgG2a κ
• Applications: ELISA, IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Store the F7 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This F7 antibody is available for research use only.