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Factor VII Antibody

CAT: 0800-V8537-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8537-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.
CAS Number
9007-83-4
Specifications
ELISA: order Ab without BSA for coating, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P08709
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 366-466 from the human protein was used as the immunogen for the Factor VII antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
F7/3511
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Factor VII antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Factor VII antibody is available for research use only.
Storage Conditions
Store the Factor VII antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Factor VII antibody should be determined by the researcher.
Location
Secreted, cytoplasm (mitochondria)
Image Legend
IHC staining of FFPE human liver with Factor VII antibody (clone F7/3511) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Product Datasheet
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