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TIA1 Antibody

CAT: 0800-V8438SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8438SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells) . It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression) . TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL for 1 hr at RT
UniProt
P31483
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 279-380 from the human protein were used as the immunogen for the TIA1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
TIA1/1313
Applications
IF, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the TIA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TIA1 antibody is available for research use only.
Storage Conditions
Store the TIA1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the TIA1 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells with TIA1 antibody (green, clone TIA1/1313) and Reddot nuclear stain (red) .

UniProtKB · P31483

Cytotoxic granule associated RNA binding protein TIA1

TIA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P31483
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TIA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q53SS9, Q96B58
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegeneration

Biological process

ApoptosismRNA processingmRNA splicing

Cellular component

CytoplasmNucleus

Domain

Repeat

Molecular function

RNA-binding

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